Thanks to its chemical structure, Gd-BOPTA is actively transported into functioning hepatocytes, and up to 4% of the injected dose is excreted via the hepatobiliary route into the bile and, ultimately, the faeces.2, 3, 4

In view of its pharmacokinetics, MultiHance^® can be used both for dynamic and delayed, liver-specific imaging in adult and pediatric patients. Evidence shows that:

• Dynamic imaging is not affected by short-term dyspnea and respiratory motion artifacts.^5,6,7
• Delayed, liver-specific imaging offers extended opportunities for the assessment of focal liver lesions, with further increase in sensitivity and specificity for detection and characterization of liver disease over and above those provided by dynamic imaging when images are acquired 40-120 minutes after injection of the agent.^8,9,10,11

Therefore, MultiHance^® should be used when diagnostic information is essential and not available with unenhanced MRI and when delayed phase imaging is required.

The aromatic group on Gd-BOPTA also provides increased r1-relaxivity relative to that of the macrocyclic GBCAs12, 13, 14, 15 and hence greater signal intensity (SI) enhancement on T1-weighted images16. This is why MultiHance^® allows both dynamic and delayed, organ-specific imaging of the liver at a dose as low as 0.05 mmol/kg.

Therefore, the recommended dose of MultiHance^® in adult patients and children is 0.05 mmol/kg body weight (0.1 mL/kg of the 0.5 M solution). The lowest dose that provides sufficient enhancement for diagnostic purposes should be used. The dose should be calculated based on the patient’s body weight, and should not exceed the recommended dose per kilogram of body weight.1The safety of MultiHance^® has been established in numerous clinical investigations and during extensive clinical use with 35 million doses administered worldwide since its launch.^17,18,19,20

The safety of MultiHance^® has also been studied in children and in special populations, such as children and patients with impairment of renal and/or liver function.^{21,22,23,24,25,26,27,28,29,30,31,32}